Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
GAINS AND LOSSES IN A CHANGING WORLD
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Effective email marketing involves more than occasionally blasting out a newsletter. To build an effective email marketing strategy, you need a tool packed with functionality. MailChimp seems to be the best system out there, offering elegant, intuitive newsletter templates, advanced list segmentation features and marketing automation capabilities.
TAXES: Approximately $41,684 a year
A new MIT white paper, ominously entitled "Are You Prepared for the Supply Chain Talent Crisis?," bears that out. Supply chain managers need sophisticated tech skills, sure, but they also have to be adept at "high-order diplomacy," expert at general business strategy and problem solving, and able to "thrive in ambiguity," the study says.
It seems that Christmas time is here once again, and it is time again to bring in the New Year. We wish the merriest of Christmas to you and your loved ones, and we wish you happiness and prosperity in the year ahead.又该迎接新的一年了。我们向你及你的亲人们致以最美好的祝福，愿你在新的一年里事业兴旺，幸福美满！
Trends and targets in antiviral phototherapy
"There's a new type of wealth creation coming out," he told Reuters, adding China was having to adapt as the wider economy was "very materially slowing down".
May your New Year be filled with special moment, warmth, peace and happiness, the joy of covered ones near, and wishing you all the joys of Christmas and a year of happiness.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
The pair came out with a spree of punch lines, dishing them around the Beverly Hills Hilton, much to the delight of its starry audience. Mr. Damon, Meryl Streep and, naturally, Mr. Clooney were among the targets. Ms. Fey particularly had the crowd roaring with a description of 'Gravity,' which stars Sandra Bullock and Mr. Clooney.
A tender love story between a teenager and an academic, set in Italy.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
《受虐待经历影响的瑞典“女权主义外交政策”倡导者》(Sweden’s Proponent of ‘Feminist Foreign Policy,’ Shaped by Abuse)
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The Warriors are one of the best teams in NBA history, and you can put their championship run up against any team in NBA history for the best playoff performance ever. But there's also a legitimate question of what this means for the sport. If the best or second-best player of all time stands no chance against this team, what does it mean for the sport's competitiveness? It hasn't been a problem so far, thanks to an extremely wild offseason, but the question remains: what happens to a competitive sports league when it's not truly competitive at the highest level?
Most technology developers are seeing app use grow and web use decline. That means companies have to have strong, fast, meaningful mobile platforms and those that don't lose customers.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
而其他的队伍还有在尝试赢球的。小牛队，在3-13的战绩面前，骄傲地说他们不会垫底。但是，明年被认为是近年来最好的NBA选秀，有Markelle Fultz, Jayson Tatum, Lonzo Ball, Josh Jackson, Harry Gile, OG Anumoby, Ivan Rabb……等等优质球员。
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
2. Will China's stock market climb back to 6,000 points?
Upgrades to the country's industrial structure in which labor-intensive industries are being moved out of metropolitan areas contributed greatly to the demographic change, Peng Xizhe, dean of the School of Social Development and Public Policy at Shanghai-based Fudan University, told the Global Times on Tuesday.
In those days, of course, Rembrandt was the gold standard. But the Dutchman and his fellow old masters have fallen out of fashion and are no longer as coveted by collectors and investors.
Influenza neuraminidase: A druggable target for natural products
In my country, we make so much waste, we buy and throw away, buy and throw away, and yet northern countries will not share with the needy. Even when we have more than enough, we are afraid to lose some of our wealth, afraid to share. 在我的祖国，我们制造了如此之多的垃圾，我们购买商品，我们随之丢弃，买来，再丢弃。然而有些国家，有些人，却不会分享给那些真正需要的人们，甚至他们拥有的远远超过自身需要的时候。他们害怕分享，害怕失去自己的财富。
不过在这一通胡闹之余（主持人蒂娜?费举杯道：致这个美好的混乱之夜），本届金球奖(Golden Globes)颁奖典礼还是清醒地把多项重要大奖颁给了各个夺奖热门。戴维?罗素(David O. Russell)电影作品《美国骗局》(American Hustle) 揽入包括最佳喜剧片在内的三项金球奖，成为当晚最大赢家。历史剧情片《为奴十二年》(12 Years a Slave)虽在另外六个竞赛单元中失利，但最终斩获了最佳剧情片奖。
The approach has in some cases moved from the political fringes into the mainstream. Some leaders from Britain’s center-right, governing Conservative Party, for example, helped push a British exit, and since the referendum the new Conservative prime minister, Theresa May, has signaled sympathy with white identity politics.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Think you’ve had some bad job interviews this year? This survey is guaranteed tcheer you up (unless you happen tbe part of it). When staffing firm OfficeTeam asked 600 managers across North America tdescribe the most embarrassing interview blunders they had seen in 2014, here’s what they said.
The role of biosensors in the detection of emerging infectious diseases
9.Yeah, I was a badass on my high school football team! – Because I want to be seen by others in an even stronger light than I see myself。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Inside larger technology companies, female employees will be hoping for signs of change in pay and promotions — but will also be on guard, as a men’s rights backlash brews in some corners of Silicon Valley.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The S&P 500’s total return of 14% this year was 40% higher than its 25-year average annual gain. Wall Street’s chief strategists spent much of the last 12 months revising their targets higher from behind. The index printed over 50 all-time record closes, with nearly all investment management professionals racing to at least pull even. A few characteristics made the U.S. stock market particularly difficult to keep up with this year.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Rankings for Greece, Italy, Portugal and Spain fell dramatically because of the impact of the eurozone crisis, while Egypt, Myanmar and Saudi Arabia registered large falls in the wake of recent political and civil turmoil.
Inhibition of SARS coronavirus helicase by bismuth complexes
If you want a refrigerator with a screen, might as well just stick an iPad on it. Samsung unveiled a smart refrigerator this summer that connects to wi-fi to help manage groceries and leave notes behind for family members.
Despite the seemingly extensive target vetting on May 7 the Chinese embassy in Belgrade was struck by five Joint Directed Attack Munition satellite-guided bombs delivered by U.S. Air Force B-2 Spirit bombers. Three Chinese journalists—Shao Yunhuan of Xinhua and Xu Xinghu and his wife Zhu Ying of the Guangming Daily—were killed in the attack. Twenty other Chinese nationals were injured five seriously.
We will accelerate the development of emerging industries.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
"There's a new type of wealth creation coming out," he told Reuters, adding China was having to adapt as the wider economy was "very materially slowing down".
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
However, this may be balanced by a decline in European and Chinese investment, with the impact of the latter on global trade heightened if China was to engineer a partial switch from investment in resource-heavy construction to forms of infrastructure spending such as water purification that are not very commodity intensive.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Sixty-one percent of Chinese college students who graduated in 2014 are satisfied with their current jobs, a survey has revealed.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
It was the season of Light, it was the season of Darkness…
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
France, along with Belgium, has seen the largest numbers of volunteers leaving to join the Islamic State jihadist group, which has seized large parts of Syriaand Iraq.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
But John Davies, head of institutional investment in the Hong Kong team at CBRE, the property services business, says that lower prices should make the market more reliable. “The market is showing characteristics of a mature market, which institutional investors understand better,” he says.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Once you grow your hair slightly longish, be sure to play with it at every opportunity.
10. China watchers inthe United States will continue to postulate China’s declining growth rate inthe face of evidence that it is stable at over 7%. China will grow fasterin 2014 than in 2013.
Five development concept of innovation, harmonization, green, openness and sharing
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
So, before the world gets the better of you and slaps a title on your forehead, create a unique manifesto of what you think you are.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
3.Oh, yeah. That makes sense. – Because option B involves admitting that I am clueless。
China's employment situation is generally stable in the first quarter of 2016, said Li Zhong, Spokesman of the Ministry, adding that the economic downturn and structural reform, however, make employment more difficult.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Accounting and finance grads will be in demand too, the poll says. Note to college students already looking ahead to the summer: 52% of employers in the survey said they prefer to hire graduates with internship experience.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
5. "Dexter" (3.1 million)
Two days ago here in Brazil, we were shocked when we spent some time with some children living on the streets. And this is what one child told us: "I wish I was rich and if I were, I would give all the street children food, clothes, medicine, shelter and love and affection." 在巴西，我被2天前见到的情景震惊了，那时我和当地的小孩在玩耍，其中一个小孩说：“我希望我能富裕起来，然后我会给这个街道所有的小孩饭吃，给他们衣服穿，医疗，住房和爱”。
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
These artificial eyes have indeed restored sight to blind mice. And the follow-up experiments on monkeys offer a lot of hope for eventual trials on humans because monkey and human retinas work similarly.
"Protections that promote equality and diversity should not be conditional on someone's sexual orientation," he wrote. "For too long, too many people have had to hide that part of their identity in the workplace."
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Frankly, this is unlikely to be ready in time for next year, but we'll include it just in case. The second film from Laszlo Nemes, who won the foreign language Oscar earlier this year for Son of Saul, is a coming-of-age drama set in Budapest just before the first world war.
The remains of the monarch -- depicted by William Shakespeare as a monstrous hunchback and often viewed as one of English history's greatest villains -- will now be solemnly reburied in the local cathedral.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The index fell from 50.4 in October to a six-month low of 50.0.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
“…started swearing during the interview.”
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Release date: 2015
Inclusive and green finance
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The new numbers, reported by a tracking initiative called the Global Carbon Project and published in the journal Nature Geoscience, came on the eve of a United Nations summit meeting meant to harness fresh political ambition in tackling climate change. Scientists said the figures showed that vastly greater efforts would be needed to get long-term global warming within tolerable limits.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
In 2018, more business leaders will channel a potent combination of digitalisation, generational change and growing diversity, to streamline their hierarchies, distribute responsibility, and transform their organisations.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Recipient: Their Royal Highnesses The Duke and Duchess of Cambridge (joint winners)
“FKA细枝”(FKA twigs)，《两星期》(Two Weeks)，Young Turks
Take multiple measures to cut costs.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Play up being smarter than everyone, develop some obvious insecurities. Forget social skills if you happen to have any.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
That possibility was backed up by a list of top-tier cities the statistics bureau began tracking recently
This so-called “playground for millionaires” is now open to everyone. The wallet-friendly hotels, guesthouses and self-catering apartments make tours affordable. With more than 100 divine islands scattered on the Indian ocean, many activities await, such as sunbathing, fishing, diving, sailing, and going on boat tours. The Seychelles islands are blessed with a warm tropical climate all year round, so you can go there whenever you want.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
But if the U.S. can avert that Washington-made crisis, the outlook for workers finding jobs is actually looking pretty good for next year. For one thing, the damage of superstorm Sandy will have to be repaired, meaning jobs in construction and retail. Businesses, meanwhile, which have held off investing and hiring because of uncertainty over the fiscal outlook, might finally open their wallets. That means more jobs, too.[qh]
Anti-HIV drug repurposing against SARS-CoV-2
The base hopes to keep up public awareness of pandas and the necessity of conservation of their natural habitats while Increasing the wild population by reintroducing individuals into areas in China where populations have declined.
Not every band can sound fresh 40 years into a career, but not every band is Blondie.
Length-scale dependence of protein hydration-shell density
Iron Man was Downey’s only movie of 2013, while Johnson had one huge film, Fast & Furious 6; one big film, G.I. Joe: Retaliation; and two smaller films. Together they added up to $1.3 billion at the global box office.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The deal makes a millionaire of 17-year-old Mr D’Aloisio, who taught himself to write software aged 12 and will join Yahoo’s London office while he continues his studies at school.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Without a cellphone at hand, Sun tried yelling to get the attention of people outside, but no one responded as time passed by.
A cheery New Year hold lots of happiness for you!
In the original casting, Michael Keaton was set to play the character. However, ABC executives begged the writers and producers to keep Jack alive. They believed the character was too likeable to die off so quickly. The writers agreed. Michael Keaton was not interested in signing up for a long-running show. Instead, the role of Jack was given to Matthew Fox. The rest is TV history.
About this collection
从一开始，社交网络就被有效地隔离在互联网之外。比如，Facebook的海量内容通常不会显示在谷歌( Google )搜索结果之中。但是否非得是这种情形？比方说，Twitter搜索结果自动出现在一个标准的谷歌搜索显示页面，岂不是更方便？再比如，当你搜索Yelp时，为什么关于某家餐厅的最新Twitter消息没有显现出来呢？由于利益相悖，不同社交网络往往把各自的内容封锁在专利保护墙之内，但也有不少工具致力于创造性地弥合这道鸿沟。需要说明的是，本文作者的公司已经开发出了这样一种工具。